Table 4.

CAR T cell trials for glioblastoma.

Trial name ClinicalTrial.gov identifier	Phase	CAR generation	Targets	Associated treatments in active arm	Sample size(evaluable patients)	Median PFS(months)	MedianOS(months)	Primary endpoint	Results
NCT01109095 (171)	I	Second	HER2 and CMV pp65	None	16	NA	24.8 months for children and 30 months for adults	Safety and feasibility	Positive
NCT02442297	I	Second	HER2	None	28	Ongoing	Ongoing	Safety and feasibility	Ongoing
NCT02208362 (172)	I	Second	IL13Rα2	None	92	Ongoing	Ongoing	Safety and feasibility	Ongoing
NCT02209376 (173)	I	Unknown	EGFRvIII	None	10	Not evaluable	8 months	Safety and feasibility	CAR T cells seen to traffic to tumours, however adaptive changes in TME need to be accounted for
NCT02664363	I	Third	EGFRvIII	TMZ induced lymphodepletion	3	Ongoing	Ongoing	MTD	Ongoing
NCT04003649	I	Second	IL-13Rα2	Ipilimumab and Nivolumab	60	Ongoing	Ongoing	Safety and feasibility	Ongoing
INTERCEPT NCT03283631	I	Unknown	EGFRvIII	None	24	Ongoing	Ongoing	MTD	Ongoing
NCT02844062	I	Unknown	EGFRvIII	None	20	Ongoing	Ongoing	Saftey and feasibility	Ongoing
NCT03726515 (174)	I	Unknown	EGFRvIII	Pembrolizumab	7	Ongoing	Ongoing	Safety, feasibility, OS and PFS	Ongoing
NCT04077866	I	Unknown	B7-H3	TMZ	40	Ongoing	Ongoing	OS	Ongoing
NCT04045847	I	Unknown	CD147	None	31	Ongoing	Ongoing	Safety and feasibility	Ongoing
NCT02937844	I	Second	PD-L1 (PD-1 on CAR T cell linked to co-stimulatory CD28 cytoplasmic domain)	Cyclophosphamide and Fludarabine	20	Ongoing	Ongoing	Safety and feasibility	Ongoing
NCT04270461	I	Third	NKG2D	None	10	Ongoing	Ongoing	Safety and feasibility	Ongoing
NCT04385173	I	Unknown	B7-H3	TMZ	12	Ongoing	Ongoing	Safety, feasibility, OS and PFS	Ongoing
NCT01454596	I/II	Third	EGFRvIII	Chemotherapy induced lumphodepletion and aldesleukin	18	Ongoing	Ongoing	Safety, feasibility and PFS6	Ongoing

PFS, progression free survival; OS, overall survival; MTD, maximum tolerated dose.