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. 2020 Oct 28;8(2):e001262. doi: 10.1136/jitc-2020-001262

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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MAHA⁺ mice have increased histamine after IC injection blood was collected by cardiac bleed 1 hour after injection of IC. Serum was isolated and histamine levels were determined by ELISA (n=8/group). No significant difference was detected between MAHA⁺ IT-IC and IV-IC groups (p=0.54); However, MAHA⁺ IT-IC and MAHA⁺ IV-IC histamine levels were significantly elevated compared with MAHA⁻ mice after IC injection (p=0.012 and p=0.0088, respectively). Welch analysis of variance was used to compare groups. *P<0.05, **P<0.01. IC, immunocytokine; IT-IC, intratumoral delivered immunocytokine; IV-IC, intravenously administered immunocytokine; OD, Optical Density; MAHA, mouse anti-human antibody; ns, not significant.