Table 2.
Baseline characteristics of participants
| Clinical hearing assessment cohort (n = 936) | Audiometric hearing assessment cohort (n = 379) | |
|---|---|---|
| n (%) | n (%) | |
| Sex | ||
| Male | 505 (54) | 201 (53) |
| Female | 431 (46) | 178 (47) |
| Age, years | ||
| 13–19 | 45 (5) | 23 (6) |
| 20–29 | 241 (26) | 99 (26) |
| 30–39 | 355 (38) | 151 (40) |
| 40–49 | 172 (18) | 68 (18) |
| ≥50 | 123 (13) | 38 (10) |
| Weekly AG dose, mg/week | ||
| Low (<3000) | 237 (25) | 88 (23) |
| Medium (3000–4999) | 422 (45) | 175 (46) |
| High (≥5000) | 276 (30) | 116 (31) |
| Standardized weekly AG dose, mg/kg/week | ||
| Low (<75) | 596 (64) | 235 (62) |
| High (≥75) | 330 (35) | 144 (38) |
| HIV status and CD4 count, cells/mm3 | ||
| HIV-negative | 239 (26) | 86 (23) |
| HIV-positive with CD4 >200 | 282 (30) | 127 (34) |
| HIV-positive with CD4 <200 | 320 (34) | 130 (34) |
| Unknown CD4 count | 95 (10) | 36 (9) |
| ART status among HIV-infected | (n = 697) | (n = 293) |
| No ART at baseline | 265 (38) | 107 (37) |
| On ART at baseline | 432 (62) | 186 (63) |
| Previous history of DR-TB | ||
| New DR-TB | 478 (51) | 190 (50) |
| Ever had prior TB | 421 (45) | 177 (47) |
| Unknown | 37 (4) | 12 (3) |
| Pre-existing composite hearing loss* | ||
| Normal hearing | 568 (60) | 183 (48) |
| Baseline hearing loss | 366 (39) | 196 (52) |
| Unknown | 2 (1) | 0 (0) |
| BMI, kg/m2 | ||
| Underweight (<18.5) | 329 (35) | 139 (36) |
| Normal (18.5–24.9) | 445 (48) | 184 (48) |
| Overweight or obese (>25) | 153 (16) | 56 (16) |
| Unknown | 9 (1) | 0 (0) |
| Serum albumin, g/l | ||
| Normal (≥35) | 193 (21) | 86 (23) |
| Hypoalbuminemia (<35) | 551 (59) | 210 (55) |
| Unknown | 192 (20) | 83 (22) |
| eGFR, ml/min/1.73 m2 | ||
| ≥90 | 590 (63) | 249 (66) |
| 60–89 | 196 (21) | 82 (21) |
| <60 | 66 (7) | 20 (5) |
| Unknown | 84 (9) | 28 (7) |
| NCM intervention of parent study | ||
| Intervention site | 430 (46) | 205 (54) |
| Control site | 506 (54) | 174 (46) |
*
Pre-existing composite hearing loss defined as confirmed by either audiometry or self-reported auditory symptoms.
AG = aminoglycoside; HIV = human immunodeficiency virus; CD4 = cluster of differentiation 4; ART = antiretroviral therapy; DR-TB = drug-resistant tuberculosis; BMI = body mass index; eGFR = estimated glomerular filtration rate; NCM = nurse case management.