Table 3.
HRs for HL
| Clinically determined hearing loss (n = 936) | Audiometric hearing loss (n =379) | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | aHR (95% CI) | HR (95% CI) | aHR (95% CI) |
| Standardized weekly AG dose, mg/kg/week* | ||||
| 1 | 1 | |||
| <75 | 1 (Reference) | 1 (Reference) | Reference | Reference |
| ≥75 | 1.25 (1.03–1.53) | 1.33 (1.09–1.64) | 1.21 (0.94–1.57) | 1.34 (1.02–1.77) |
| Age (10 years old) | 1.00 (0.92–1.10) | 1.02 (0.93–1.12) | 1.22 (1.08–1.38) | 1.16 (1.01–1.33) |
| eGFR, ml/min/1.73m2 | 1.00 (1.00–1.00) | 1.00 (0.99–1.00) | 1.00 (0.99–1.00) | 0.99 (0.99–1.00) |
| Pre-existing composite HL† | — | — | ||
| Normal hearing | 1 (Reference) | 1 (Reference) | ||
| Baseline HL | 1.67 (1.38–2.02) | 1.68 (1.38–2.07) | ||
| Pre-existing audiometric HL | — | — | ||
| Normal hearing | 1 (Reference) | 1 (Reference) | ||
| Baseline HL | 1.64 (1.25–2.14) | 1.71 (1.29–2.27) | ||
| Type of audiometer | — | — | ||
| Audio booth | 1 (Reference) | 1 (Reference) | ||
| KUDUwave | 1.21 (0.94–1.56) | 1.12 (0.82–1.52) | ||
| Type of AG | ||||
| Amikacin | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Kanamycin | 2.18 (1.43–3.32) | 2.95 (1.68–5.19) | 1.64 (1.03–2.62) | 1.31 (0.70–2.46) |
| NCM intervention | ||||
| Intervention site | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Control site | 1.12 (0.92–1.35) | 1.01 (0.82–1.24) | 1.33 (1.03–1.72) | 1.41 (1.03–1.94) |
| HIV status‡ | — | — | ||
| Negative | 1 (Reference) | 1 (Reference) | ||
| Positive | 1.21 (0.96–1.52) | 1.20 (0.88–1.64) | ||
*
Dichotomized due to lack of statistical differences between low exposure (<60 mg/kg/week) and intermediate exposure (60–74.9 mg/kg/week) patients if AG dose was <75 mg/kg/week.
†
Defined as confirmed by either audiometry or self-reported auditory symptoms.
‡
Not retained in the multivariate model.
HR = hazard ratio; HL= hearing loss; CI= confidence interval; aHR = adjusted HR; AG = aminoglycoside; eGFR = estimated glomerular filtration rate; NCM = nurse case management; HIV = human immunodeficiency virus.