Table 1.
Patient demographics and response
| Patient # | Dose Level / Number of Infusions Weekly | Age / Sex | PS | Pathology | Prior Treatments | Tumor Location Prior to NK Cell Infusion | Number of Infusions Received | Clinical /Radiological Response | Comments |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 / 3 | 18 /M | 80 | Medulloblastoma | 2 therapies | PF, LMD extending into foramen magnum | 21 / 27 | PD | Excluded from radiomic analysis, as had LMD only |
| 2 | 1 / 3 | 11 / M | 80 | Ependymoma | 3 surgeries/1 radiation therapy (chemo naïve) | Fourth ventricular tumor | 27 / 27 | PD | |
| 3 | 1 /3 | 15 / M | 80 | Medulloblastoma | 3 therapies | Fourth ventricular tumor, LMD across cerebellum | 9 / 27 | PD | |
| 4 | 2 / 3 | 16 / F | 60. | Medulloblastoma | 1 therapy | Tumor in cerebellar vermis, with LMD across PF | 24/27 | PD | Slurring of speech with dysphagia during second cycle, given steroids empirically for inflammation, symptoms improved, progressive gait and dysmetria at end of therapy for PD |
| 5 | 2 / 1 | 18 / F | 70 | Medulloblastoma | 3 therapies | Tumor recurrence at the left side of falx cerebi, hemorrhagic | 9/9 | PD | Excluded from radiomic analysis, as had hemorrhage in tumor |
| 6 | 2 /1 | 11 / M | 90 | Ependymoma | 3 surgeries and twice radiation therapy | Fourth ventricular mass extending into foramen of Luschka | 6//9 | PD | Increasing dysmetria after 6 infusions with evidence of PD |
| 7 | 3 / 1 | 9 / M | 70 | Ependymoma | 1 surgery and CSI | Fourth ventricular tumor extending into foramen of Luschka | 9/9 | PD, gait worsened | Dysarthria, gait abnormalities at beginning of treatment, these increased at end of therapy with PD, postoperative pseudomeningocele |
| 8 | 3 / 1 | 8 / M | 80 | Medulloblastoma | 1 surgery, 1 radiation therapy, and 2 lines of chemotherapy | Large right periventricular nodule with LMD in cerebellum | 5/9 | Radiographic response after 5 infusions (SD as decrease in size was <50%). No clinical improvement, PD after 3 weeks | 1 episode of seizure after 5th infusion, MRI showed decrease in size of lesion, received steroids for 2 days empirically for inflammation. No further infusions as patient progressed later to PD |
| 9 | 3 / 1 | 9 / F | 80 | Ependymoma | 3 surgeries, twice radiation therapy, vaccine therapy, and one targeted intrathecal chemotherapy | Multilocular mass along fourth ventricle, extending to foramen magnum | 2/9 | Tumor size slowly increased (SD) after 2 infusions, parents decided take off therapy. MRI remained same size (SD), noted 30 days after last NK cell infusion (end of study follow-up) | Patient taken off treatment per parental wish |
Abbreviations: CSI, craniospinal irradiation; LMD, leptomeningeal disease; PS, performance score; PF, posterior fossa; PD, progressive disease; SD, stable disease.