Fig. 10.

Selected recently completed or ongoing trials with targeted molecular therapies. CDK = cyclin-dependent kinase; EGF = epidermal growth factor; EGFR = epidermal growth factor receptor; FGFR = fibroblast growth factor receptor; GF = growth factor; HDAC = histone deacetylase; HSP = heat shock protein; MDM2 = murine double minute 2; mTOR = mammalian target of rapamycin; PARP = poly(ADP-ribose) polymerase; PDGFR = platelet derived growth factor receptor; PKC = protein kinase C; RTK = receptor tyrosine kinase; TGF-β = transforming growth factor beta; TGFβR = transforming growth factor beta receptor; TrK = tropomyosin receptor kinase; VEGF = vascular endothelial growth factor; VEGFR = vascular endothelial growth factor receptor; XPO1 = exportin 1.