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. 2020 Oct 27;61(12):25. doi: 10.1167/iovs.61.12.25

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Figure 4. — Augmented expression of HSP70 in Rpgrip1⁻^/⁻ mice. (A) Immunoblots confirm the expression of TgCrx-Hspa1a-Flag transgene and elevated total HSP70 protein level in Rpgrip1⁻^/⁻ mice at P40. (B) ONL thickness is not different between Rpgrip1⁻^/⁻; TgHspa1a- (n = 7) and Rpgrip1⁻^/⁻; TgHspa1a+ (n = 8) mice at P40. (C) Representative picture of central and peripheral region of H&E stained retinal cross-sections from Rpgrip1⁻^/⁻; TgHspa1a- and Rpgrip1⁻^/⁻; TgHspa1a+ mice at P40. (D) Plots of scotopic and photopic ERG amplitudes of Rpgrip1⁻^/⁻; TgHspa1a- (n = 14), and Rpgrip1⁻^/⁻; TgHspa1a+ (n = 18) mice at P30 and P40. Scale bar: 25 μm for all panels. Error bar: SEM. Student's t-test, *P < 0.05, **P < 0.01.