Table 8.
Expression quantitative trait loci associated with CCHCR1 single-nucleotide variations in diabetes-related tissues
| SNV | Gene symbol | P | NES | Tissue |
|---|---|---|---|---|
| rs2073721 | CCHCR1 | 3.00 × 10–56 | –0.6 | Muscle—skeletal |
| HCG27 | 9.90 × 10–19 | 0.38 | Adipose—subcutaneous | |
| 7.90 × 10–10 | 0.3 | Adipose—visceral (Omentum) | ||
| 1.10 × 10–09 | 0.44 | Liver | ||
| 1.50 × 10–08 | 0.38 | Pancreas | ||
| 6.80 × 10–07 | 0.18 | Muscle—skeletal | ||
| PSORS1C2 | 2.10 × 10–17 | 0.5 | Adipose—subcutaneous | |
| 4.70 × 10–10 | 0.41 | Adipose—visceral (Omentum) | ||
| 1.80 × 10–07 | 0.49 | Liver | ||
| HLA-L | 2.30 × 10–14 | 0.38 | Adipose—subcutaneous | |
| 5.90 × 10–10 | 0.36 | Adipose—visceral (Omentum) | ||
| 2.70 × 10–08 | 0.28 | Muscle—skeletal | ||
| HCG22 | 1.40 × 10–13 | –0.39 | Adipose—subcutaneous | |
| 3.90 × 10–11 | –0.39 | Adipose—visceral (Omentum) | ||
| PSORS1C1 | 1.30 × 10–09 | 0.33 | Adipose—visceral (Omentum) | |
| 8.30 × 10–09 | 0.3 | Adipose—subcutaneous | ||
| 1.30 × 10–08 | 0.31 | Muscle—skeletal | ||
| DDAH2 | 9.70 × 10–07 | –0.13 | Adipose—visceral (Omentum) | |
| rs3131012 | CCHCR1 | 3.40 × 10–30 | –0.39 | Muscle—skeletal |
| 1.60 × 10–09 | 0.2 | Adipose—subcutaneous | ||
| HCG27 | 2.30 × 10–15 | 0.3 | Adipose—subcutaneous | |
| 6.90 × 10–10 | 0.26 | Adipose—visceral (Omentum) | ||
| 8.10 × 10–10 | 0.42 | Liver | ||
| 1.30 × 10–09 | 0.19 | Muscle—skeletal | ||
| XXbac-BPG299F13.17 | 1.20 × 10–07 | 0.16 | Muscle—skeletal | |
| rs3130453 | CCHCR1 | 6.20 × 10–22 | –0.33 | Muscle—skeletal |
| PSORS1C1 | 2.00 × 10–15 | 0.35 | Adipose—subcutaneous | |
| 1.90 × 10–11 | 0.33 | Adipose—visceral (Omentum) | ||
| 7.50 × 10–09 | 0.27 | Muscle—skeletal | ||
| PSORS1C2 | 9.20 × 10–15 | 0.4 | Adipose—subcutaneous | |
| 4.40 × 10–11 | 0.39 | Adipose—visceral (Omentum) | ||
| HLA-B | 8.30 × 10–09 | 0.26 | Pancreas | |
| 2.60 × 10–07 | 0.14 | Adipose—subcutaneous | ||
| 2.90 × 10–07 | 0.13 | Muscle—skeletal | ||
| 9.00 × 10–07 | 0.17 | Adipose—visceral (Omentum) | ||
| HLA-L | 2.20 × 10–09 | 0.26 | Adipose—subcutaneous | |
| 1.70 × 10–08 | 0.24 | Muscle—skeletal | ||
| 2.30 × 10–07 | 0.37 | Pancreas | ||
| 6.50 × 10–07 | 0.26 | Adipose—visceral (Omentum) | ||
| XXbac-BPG181B23.7 | 1.80 × 10–07 | –0.27 | Adipose—subcutaneous | |
| 1.40 × 10–07 | –0.23 | Adipose—visceral (Omentum) |
Abbreviations: CCHCR1, coiled-coil α-helical rod protein 1; HLA, human leukocyte antigen; NES, normalized effect size; SNV, single-nucleotide variation.