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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2020 Jul 17;402:115138. doi: 10.1016/j.taap.2020.115138

Figure 5: Pharmacological inhibition of NRF2 slows NSCLC cell migration and invasion.

Figure 5:

Representative images at 24 hours post scratch of (A) H1299 (WT) and (B) H1299 KEAP1−/− (KO) cells that were treated with 40 nM brusatol for 16 hours prior to scratch (white dashed lines indicate scratch edges). Wound closure percent of (C) WT and (D) KO cells at 0, 6, 12, 18, and 24 hours post scratch (n=3). (E) WT and KO cells were treated with 40 nM brusatol and serum starved overnight prior to measuring invasive behavior via number of cells that migrated to bottom chamber 24 hours post seeding (n=5–6); (*p<0.05).