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. 2020 Oct 23;27(1):1397–1411. doi: 10.1080/10717544.2020.1827085

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Physicochemical characterization of nanoparticles. (A) Encapsulation efficiency and drug loading of nanoparticles without or with sucrose laurate. (B) Agarose gel electrophoresis of nanoparticles complexed with siRNA; Lane (1): naked siRNA. Lanes (2–7): the weight ratios of lipids to siRNA were (2) 0.6/1, (3) 1.2/1, (4) 2.4/1, (5) 4.8/1, (6) 9.6/1, and (7) 19.2/1. (C) Zeta potentials and (D) sizes of liposomes detected by DLS. (E) TEM images of various nanoparticles. Nanoparticles were negatively stained with 2.0% phosphotungstic acid and observed by transmission electron microscopy. Data are shown as mean ± SD (n = 3).