Table 2.

Inhibition of tau and Aβ₄₂ aggregation and BACE1 by compounds 17–26 (series II).

Cmpd.	n	R	In cellulo tau inhibition %a	In cellulo Aβ42 inhibition %a	hBACE1 %b or IC50c (μM)
17	2		58.6 ± 4.5	55.7 ± 2.8	4.09 ± 0.11
18	3		ndd	ndd	4.58 ± 0.21
19	5		ndd	ndd	7.23 ± 0.38
20	6		64.0 ± 5.1	66.9 ± 3.9	62.1% ± 5.8
21	4		41.3 ± 6.3	12.2 ± 4.1	21.88 ± 1.16
22	5		44.3 ± 6.5	25.2 ± 3.4	63.9% ± 7.7
23	6		28.4 ± 3.8	16.4 ± 2.8	30.88 ± 1.58
24	7		55.6 ± 4.2	21.4 ± 3.4	21.73 ± 1.57
25	2		27.8 ± 5.3	34.6 ± 3.0	65.7% ± 5.5
26	3		21.2 ± 4.9	29.9 ± 3.4	37.53 ± 1.31

^aThe percent of inhibition at 10 µM (mean of three experiments ± SEM).

^bThe percent of inhibition at 10 µM (mean of three experiments ± SD).

^cMean of three experiments ± SEM.

^dNot determined.