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. Author manuscript; available in PMC: 2020 Oct 29.
Published in final edited form as: J Mol Biol. 2018 Jan 4;430(5):655–667. doi: 10.1016/j.jmb.2018.01.001

Fig. 6.

Fig. 6.

Schematic diagram of an architectural DNA-binding protein traveling along DNA. Pink and blue represent the DNA-binding protein and DNA, respectively. The binding of architectural proteins to DNA is accompanied by large conformational changes in the DNA structure, including changes in helical twist, major and minor groove widths (shown in inset), and axis curvature. Red arrows represent rotation-coupled sliding along DNA. The changes in DNA structure coupled to binding result in a high free-energy barrier, thereby retarding 1D diffusion along DNA.