Table 2.
Inhibition effect of repurposed drugs on SARS and MERS spike protein pseudovirus infection.
| Name | Huh-7 | SARS-CoV S pseudovirus | MERS-CoV S pseudovirus | ||
|---|---|---|---|---|---|
| CC50 (µM) | EC90 (µM) | EC50 (µM) | EC90 (µM) | EC50 (µM) | |
| Bosutinib | 13.58 ± 2.16 | 3.15 ± 0.01 | 1.04 ± 0.05 | 2.44 ± 1.38 | 1.25 ± 0.01 |
| Amiodarone | 11.01 ± 2.57 | >20 | 0.60 ± 0.37 | >20 | 0.74 ± 0.06 |
| Flupenthixol | 14.72 ± 3.28 | 10.81 ± 1.05 | 1.39 ± 0.35 | 6.80 ± 0.40 | 1.68 ± 0.22 |
| Trimeprazine | 16.68 ± 1.89 | 4.30 ± 0.48 | 0.66 ± 0.45 | 3.78 ± 1.54 | 0.73 ± 0.13 |
| Azelastine | >20 | >20 | 2.36 ± 1.57 | >20 | 2.59 ± 0.88 |
| Clemastine | 6.60 ± 1.48 | 12.44 ± 1.24 | 1.79 ± 0.32 | >20 | 1.05 ± 0.26 |
| Toremifene | >20 | >20 | 2.28 ± 1.09 | >20 | 3.49 ± 0.44 |
Data present as mean ± SEM from two independent experiments.