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. 2020 Apr 8;75(8):2091–2094. doi: 10.1111/all.14271

TABLE 1.

Overall sensitivity of molecular test methods increased with higher sIgE to D.p. extract

sIgE to D.p. extract n ISAC (%) P‐value ImmunoCAP molecular (%) P‐value ALEX P‐value ALEX2 P‐value
Overall 215 88.8 <.001 93.0 <.001 93.5 <.001 94.9 .001
≥0.7 kU/L 204 89.7 <.001 94.6 .001 94.6 .001 95.6 .004
≥1.0 kU/L 186 93.6 <.001 96.2 .016 96.8 .031 97.3 .063
≥3.5 kU/L 141 97.9 .250 99.3 1.000 99.3 1.000 99.3 1.000

Sensitivity of the four molecular assays tested increased with sIgE levels to D.p. extract. In the case of sIgE levels ≥ 1.0 kU/L, ALEX2 and in the case of sIgE levels ≥ 3.5 kU/L, all molecular assays performed statistically equal to extract‐based diagnosis. All P‐values listed are direct comparisons to extract‐based singleplex diagnosis using ImmunoCAP.