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. 2020 Oct 28;11(10):924. doi: 10.1038/s41419-020-03127-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — There are two major subtypes of EVs known as the Exos and the MVs. Exos are released by the fusion of plasma membrane with MVB which is generated by inward budding of endosome. While MVs are released by direct outward budding of plasma membrane. During cellular uptake, contents within released EVs from parent cells can be transmitted into the cytoplasm of receptor cells by membrane fusion and/or endocytosis. In this endocytosis process, clathrin-mediated endocytosis (CME), macropinocytosis, and phagocytosis are regarded as the most common pathways.