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. 2020 Oct 28;10:18489. doi: 10.1038/s41598-020-75578-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dinaciclib treatment and expression of CDK2/5/9 in CCA. (A) CHNG6, patient derived xenograft cells (PDXC) were subjected to a high throughput-drug screening and is significantly sensitive to dinaciclib at low nanomolar concentrations. (B) Relative mRNA expression of CDK2/5/9 are overexpressed in cholangiocarcinoma samples relative to normal samples from cBioportal database. mRNA expression was available for thirty-five tumor and ten normal samples. Expression of CDK’s was normalized with normal samples and the data presented as box plots. (C) Copy number analysis of thirty-five tumor samples from the cBioportal database indicates subsets of CCA samples with copy number gain in CDK2, CDK5 and CDK9. Copy number gain is presented in percentages.