Table 3.
Description of the nine chromosomal regions associated with health-related traits and the annotated candidate genes.
| Region | Chr | Start (Mbp) | End (Mbp) | N SNPs | Top SNPs | MAF | p-value | FDR | Trait | Candidate genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | 8.39 | 1 | rs319560097 | 0.44 | 1.71E−06 | 7.29E−02 | IgG | SLA, ST3GAL1 | |
| 2 | 4 | 90.54 | 91.26 | 10 | rs81233340, rs81382318 | 0.15 | 7.17E−09 | 1.53E−04 | CRP | CRP |
| 3 | 6 | 17.11 | 17.18 | 2 | rs338661853 | 0.50 | 1.78E−06 | 6.81E−02 | LYM_PHAGO_FITC | CDH1, COG8, VPS4A |
| 4 | 6 | 164.85 | 165.78 | 10 | rs323656844 | 0.43 | 1.73E−06 | 2.18E−02 | MCV, MCH* | PRDX1, PIK3R3 |
| 5 | 17 | 52.47 | 52.51 | 3 | rs80924885, rs80899023, rs80803525 | 0.33 | 5.68E−06 | 8.07E−02 | LYM | NFATC2 |
| 6 | X | 33.51 | 33.64 | 5 | rs342772739 | 0.13 | 2.71E−06 | 2.71E−02 | γδ T cells | ssc-mir-9786-1 |
| 7 | 12 | 3.25 | 1 | rs323856019 | 0.17 | 3.26E−06 | 1.39E−01 | LEU | SOCS3, BIRC5 | |
| 8 | 13 | 69.03 | 71.96 | 7 | rs81270251 | 0.48 | 9.01E−06 | 1.24E−01 | NEU | GATA2, PPARG, RAF1, SEC61A1 |
| 9 | 14 | 123.89 | 1 | rs343667976 | 0.45 | 9.07E−06 | 1.93E−01 | LEU | – |
* most significant trait