Table 1.
Clinicopathologic characteristics of the study cohort.
| HPV (−) | HPV (+) | P value | |
|---|---|---|---|
| N | 83 (53%) | 74 (47%) | |
| Sex | 0.126 | ||
| Female | 27 (33%) | 16 (22%) | |
| Male | 56 (67%) | 58 (78%) | |
| Age, median (range) | 61 (27 – 79) | 59 (35–84) | 0.445 |
| Smoking history | 0.002 | ||
| Unknown | 1 (1%) | 0 | |
| No | 7 (8%) | 20 (27%) | |
| Yes | 75 (90%) | 54 (73%) | |
| < 10 pack/years | 2 (2%) | 9 (12%) | |
| > 10 pack/years | 71 (86%) | 42 (57%) | |
| Unknown quantity | 2 (2%) | 3 (4%) | |
| Site of origin | < 0.001 | ||
| Base of tongue | 30 (36%) | 37 (50%) | |
| Tonsil | 18 (22%) | 29 (39%) | |
| Soft palate | 35 (42%) | 8 (11%) | |
| Clinical T staging | 0.183 | ||
| TX | 1 (1%) | 0 | |
| T1/T2 | 49 (59%) | 52 (70%) | |
| T3/T4 | 33 (40%) | 22 (30%) | |
| Clinical N staging | 0.02 | ||
| N0 | 38 (46%) | 20 (27%) | |
| N+ | 45 (54%) | 54 (73%) | |
| Perineural invasion | 0.171 | ||
| Unknown | 23 (28%) | 13 (18%) | |
| Absent | 43 (52%) | 49 (66%) | |
| Present | 17 (20%) | 12 (16%) | |
| Vascular invasion | 0.264 | ||
| Unknown | 21 (25%) | 13 (18%) | |
| Absent | 41 (49%) | 49 (66%) | |
| Present | 17 (25%) | 15 (20%) | |
| Surgical margin status | 0.791 | ||
| Unknown | 1 (1%) | 2 (3%) | |
| Negative | 43 (52%) | 38 (51%) | |
| Positive or close (<5 mm) | 39 (47%) | 34 (46%) | |
| AJCC pT staging | 0.313 | ||
| T1/T2 | 58 (70%) | 57 (77%) | |
| T3/T4 | 25 (30%) | 17 (23%) | |
| AJCC pN staging | 0.005 | ||
| Nx | 1 (1%) | 0 | |
| N0 | 40 (48%) | 19 (26%) | |
| N+ | 42 (51%) | 55 (74%) | |
| Post-operative radiation | 0.008 | ||
| No | 33 (40%) | 15 (20%) | |
| Yes | 50 (60%) | 59 (80%) | |
| Follow up period, months, median (range) | 153 (9 – 213) | 182 (0.2 – 291) | 0.626 |
| Overall survival status | NA | ||
| Deceased | 75 (90%) | 40 (54%) | |
| Alive | 8 10%) | 34 (46%) | |
| Progression free survival status | NA | ||
| Progressed | 38 (46%) | 18 (24%) | |
| Not progressed | 45 (54%) | 56 (76%) | |
| Local recurrence | NA | ||
| Absent | 60 (72%) | 66 (89%) | |
| Present | 23 (28%) | 8 (11%) | |
| Regional recurrence | NA | ||
| Absent | 71 (86%) | 67 (91%) | |
| Present | 12 (14%) | 7 (9%) | |
| Distant metastasis | NA | ||
| Absent | 68 (82%) | 67 (91%) | |
| Present | 15 (18%) | 7 (9%) | |
a
P values were obtained using Fisher’s Exact test or Chi-square test for nonparametric and two-tailed Student’s t test for continuous variables.
b
Deceased patients were excluded from the calculation.
Abbreviations: HPV=human papillomavirus; AJCC=American Joint Committee on Cancer, NA=not applicable.