Fig. 4. Parasite multiplication rates correlate significantly with levels of parasitaemia measured in patients.

a Univariate significant correlation with patient parasitaemia levels for multiplication rates assayed after 153 days of culture (earlier culture timepoints showed similar positive correlations). b Multiple regression analysis adjusting for patient age and haemoglobin levels shows a significant positive correlation between multiplication rates and patient parasitaemia at all culture timepoints. The coefficient on the x-axis is equivalent to the standard z-score with 95% confidence intervals. There were non-significant residual negative correlations with haemoglobin levels, and slight positive residual correlations with age. P-values are indicated for statistically significant correlations. Data for each of the variables in individual patients are given in Table 1, and the multiple regression coefficients are given in Supplementary Table S4.