Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 28;10:18433. doi: 10.1038/s41598-020-74128-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Signal transduction enrichment analysis in human SCs and fibroblasts. The data reflects the output analysis obtained from enrichR using the databases from GO biological processes and Reactome according to the enrichment score (x axis). The bar graphs were adapted directly from the enrichR output display of the indicated enriched terms which comprise the modules of signal transduction that were most highly represented in the input datasets for those genes expressed only in fibroblasts and SCs. As expected, pathway enrichment highlighted genes and networks responsible for collagen synthesis, ECM remodeling (assembly/disassembly) and basal lamina organization in fibroblasts. In SCs, the pathways with the highest scores were those involved in PNS development, maintenance and regeneration as well as cell–cell signaling mediating homophilic and heterophilic interactions with nerve cells. The Reactome database unraveled enrichment in MAPK signaling components in proliferative human SCs. This finding was expected because of the presence of neuregulin in the culture medium^15,16. Pathways involved in neural regulation in fibroblasts were highlighted by GO biological processes and Reactome.