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. 2020 Oct 28;10:18519. doi: 10.1038/s41598-020-74575-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of cell motility results for A549 epithelial cells and WI-38 fibroblasts on different substrates: (A) A diagram to indicate “Major cell population movement” and “leading cell distance”. (B) A comparison of cell motility results for the major cell population movement for A549 epithelial cells attached on fibronectin coated PDMS substrates, A549 epithelial cells attached on collagen coated PDMS substrates, and WI-38 fibroblasts attached on fibronectin coated PDMS substrates with stiffnesses including 10 kPa, 200 kPa, 800 kPa and glass. Data are standard deviation. (C) A comparison of cell motility results with the leading cell movement for A549 epithelial cells attached on fibronectin coated PDMS substrates, A549 epithelial cells attached on collagen coated PDMS substrates, and WI-38 fibroblasts attached on fibronectin coated PDMS substrates with stiffnesses from 10 kPa, 200 kPa, 800 kPa and glass. The difference in cell response between the two cell types to substrate stiffness is statistically significant (P values < 10^–5 between the epithelial cells and the fibroblasts for both the 90% distribution and the leading cell movement).