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. 2020 Oct 28;11(10):926. doi: 10.1038/s41419-020-03108-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Chemical structure of ZJQ-24. B Compound ZJQ-24 docked into mTOR based on PDB code 4JT6, AKT based on PDB code 3O96. C The binding energies between ZJQ24 and proteins (mTOR, AKT and VEGFR2). D Tube formation inhibition. HUVECs were seeded on the surface of the Matrigel and treated with or without ZJQ-24. After incubation for 6 h, capillary tube formation was examined using an inverted microscope. *P < 0.05, **P < 0.01 vs. control group.