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. 2020 Oct 28;10:18415. doi: 10.1038/s41598-020-75621-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction between ghrelin and GLP-1 on food intake. (A) Preadministration of ghrelin 30 min before GLP-1 abolished GLP-1‒induced suppression of feeding in rats fed ad libitum (n = 8). (B) GLP-1 administration to rats in the dark phase suppressed feeding, while preadministration of ghrelin 30 min before GLP-1 abolished GLP-1-induced suppression of feeding in rats fed ad libitum (n = 6). (C) Preadministration of GLP-1 30 min before ghrelin abolished ghrelin-induced feeding in rats fasted 8 h (n = 8). (D) Preadministration of ghrelin 30 min before GLP-1 abolished GLP-1‒induced suppression of feeding in mice fasted 8 h (n = 6). (E) Ghrelin did not induce food intake in Ghsr^−/− mice, and preadministration of ghrelin 30 min before GLP-1 failed to abolish GLP-1′s anorectic effect (n = 10). (F) Preadministration of ghrelin abolished GLP-1‒induced suppression of feeding in their wild type mice fasted 12 h (n = 10). (G) Preadministration of GLP-1 30 min before ghrelin to Glp1r^−/− mice fed ad libitum failed to abolish ghrelin-induced feeding (n = 8). (H) Preadministration of GLP-1 inhibited ghrelin-induced feeding in their wild type mice fed ad libitum (n = 8). All values are means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05, ns not significant.

Interaction between ghrelin and GLP-1 on food intake. (A) Preadministration of ghrelin 30 min before GLP-1 abolished GLP-1‒induced suppression of feeding in rats fed ad libitum (n = 8). (B) GLP-1 administration to rats in the dark phase suppressed feeding, while preadministration of ghrelin 30 min before GLP-1 abolished GLP-1-induced suppression of feeding in rats fed ad libitum (n = 6). (C) Preadministration of GLP-1 30 min before ghrelin abolished ghrelin-induced feeding in rats fasted 8 h (n = 8). (D) Preadministration of ghrelin 30 min before GLP-1 abolished GLP-1‒induced suppression of feeding in mice fasted 8 h (n = 6). (E) Ghrelin did not induce food intake in Ghsr^−/− mice, and preadministration of ghrelin 30 min before GLP-1 failed to abolish GLP-1′s anorectic effect (n = 10). (F) Preadministration of ghrelin abolished GLP-1‒induced suppression of feeding in their wild type mice fasted 12 h (n = 10). (G) Preadministration of GLP-1 30 min before ghrelin to Glp1r^−/− mice fed ad libitum failed to abolish ghrelin-induced feeding (n = 8). (H) Preadministration of GLP-1 inhibited ghrelin-induced feeding in their wild type mice fed ad libitum (n = 8). All values are means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05, ns not significant.