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. 2020 Oct 28;10:18517. doi: 10.1038/s41598-020-74748-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of hubs and bottlenecks in the brain protein interaction network. In networks, nodes with high degree are hubs and nodes with high betweenness centrality are bottlenecks. (a) Degree (hub-ness) is plotted against betweenness centrality (bottleneck-ness) in the brain protein interaction network for all proteins identified by IM-DIA-MS (grey circles). Of the significantly altered proteins (red circles), hub-bottleneck (> 90th percentile (PC) for degree and betweenness centrality) and nonhub-bottleneck proteins (> 90th PC for betweenness centrality) are highlighted (filled red circles). (b) Profiles of significantly altered bottleneck proteins implicated in Aβ42 toxicity. Maximum abundances are scaled to 1. Numbers in parentheses denote which cluster from Fig. 2c the protein was in.