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. 2020 Oct 29;14(10):e0008788. doi: 10.1371/journal.pntd.0008788

Fig 5. Immunizations with POWV-SEV vaccine confer protective efficacy in mice.

Fig 5

C57BL/6 mice (seven per group) were immunized with POWV-SEV (blue circles) or mMV101 vector (red filled circles) and challenged with POWV virus. (A) The percent change from initial body weight, (B) Kaplan-Meier survival curve, (C) and organ viral loads (FFU/μg RNA) post POWV viral challenge are shown. (C) Powassan viral burden in organs of pMV101- or POWV-SEV vaccinated mice at endpoint or 14 days post infection, whichever came later. The average end point for POWV-challenged pMV101-control group was 8 dpi. POWV-challenged POWV-SEV group were sacrificed at day 14 post infection. (D) Kinetics of circulating peripheral blood viral load of pMV101 or POWV-SEV-vaccinated C57BL/6 mice upon challenge (n = 7) depicting average FFU/μg RNA of each cohort. The dotted line indicates the average survival in days for control pMV101 vaccinated mice upon challenge. Error bars (C) and (D) depict the standard error of the mean. Results were compared by using Student’s t test.