Percentage of annihilation events reaching the scanner plotted as a function of scanner AFOV. Three different imaging setups were simulated: Setup A is a point source in air, Setup B is a point source in a 200 cm long water-filled cylinder, and Setup C is a uniformly distributed source in a 200 cm long water-filled cylinder. The cylinder diameter included 20 cm, 27 cm, 35 cm, and 40 cm, representing small to large patients.