Table 1. Effects of sertraline, aripiprazole and verapamil on pimozide bidirectional assay across LLC-GA5-CoL150 cell monolayers.

	Efflux Ratio	% of control
Pimozide	3.62 ± 1.04	100
+ sertraline	0.57 ± 0.07 *	15.7
+ aripiprazole	1.14 ± 0.17 *	31.4
+ verapamil	1.61 ± 0.14 *	44.6
Rho123	3.46 ± 0.25	-

The values of the efflux ratio of pimozide in the absence or presence of sertraline, aripiprazole or verapamil in LLC-GA5-CoL150 cell monolayers are shown.

Pimozide: 10 μM, sertraline: 500 μM, aripiprazole: 15 μM, verapamil: 100 μM, Rho123: 10 μM.

Values are mean ± S.E.M. (n = 3~6) and % of control (pimozide alone).

*, p < 0.05 compared with pimozide.