Table 2. Effects of sertraline, aripiprazole and verapamil on pimozide bidirectional assay across Caco-2 cell monolayers.
| Papp AtoB (×10−6 cm/sec) |
Papp BtoA (×10−6 cm/sec) |
Efflux Ratio | |
|---|---|---|---|
| Pimozide | 1.64±0.14 | 0.35±0.01 | 0.21±0.01 |
| + Sertraline | 9.72±0.71** | 0.06±0.01** | 0.01±0.00** |
| + Aripiprazole | 2.14±0.13 | 0.28±0.02** | 0.13±0.01** |
| + Verapamil | 1.58±0.12 | 0.15±0.00** | 0.09±0.00** |
| Rho123 | 4.91±0.14 | 14.48±0.33 | 2.95±0.07 |
| + Verapamil | 6.88±0.56 | 12.14±0.23 | 1.77±0.03 |
The permeability of pimozide at the concentration of 10 μM was measured in Caco-2 cell monolayers in the absence or presence of sertraline, aripiprazole or verapamil.
Pimozide: 10 μM, sertraline: 500 μM, aripiprazole: 15 μM, verapamil: 100 μM, Rho123: 10 μM.
Values are mean ± S.E.M. (n = 3).
**, p < 0.01 compared with pimozide.