Table 2.

Studies related to MMP-2-753C/T and MMP-3-1171A5/A6

MMP type	Author	Year	Periodontitis	Cases	Controls	Sample type	Country	Race	Outcome
MMP-2- 753C/T	Chen et al.[9]	2007	AgP	79	128	Oral swab	China	Chinese	Association with Ag P found in TIMP-2-418GC gene polymorphism.
	Gurkan [12]	2007	AgP	92	157	Blood sample	Turkey	Turkish	No association was observed between GAgP and polymorphism
MMP-3-1171 A5/A6	Itagaki et al.[10]	2004	AgP	37	142	Blood sample	Japan	Asian	No effect on AgP and CP in Japanese population
	Astolfi et al.[11]	2006	CP	114	109	Oral swab	Brazil	Mixed	MMP SNPs were not associated with susceptibility to periodontitis
	Loo et al.[13]	2011	CP	280	250	Blood sample	china	Asian	Association was observed between CP and MMP-1 2G/2G, MMP-3 5A/5A, MMP-9 C/C
	Letra et al.[14]	2012	CP	99	302	Saliva & gingival biopsy	Brazil	Mixed	Association was observed between MMP3 and CP disease progression

MMP = matrix metalloproteinase, AgP = aggressive periodontitis, CP = chronic periodontitis, SNP = single-nucleotide polymorphism, GAgP = generalized aggressive periodontitis