Table 1. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of liriodenine isolated from Annona macroprophyllata, evaluated in 17 fungal isolates.
| Liriodenine | Amphotericin B | Fluconazole | |||||
|---|---|---|---|---|---|---|---|
| Fungi | MIC (μg.mL-1) | MFC (μg.mL-1) | MIC (μg.mL-1) | MFC (μg.mL-1) | MIC (μg.mL-1) | MFC (μg.mL-1) | |
| Paracoccidioides brasiliensis 339 (ATCC32069) | > 500 | > 500 | 0.5 | 1 | NP | NP | |
| Paracoccidioides brasiliensis 18 | 31.2 | 31.2 | 1 | 1 | NP | NP | |
| Paracoccidioides restrepiensis 192 | 62.5 | 62.5 | 1 | 1 | NP | NP | |
| Paracoccidioides lutzii 01 (ATCC MYA-826) | > 500 | > 500 | 0.5 | 1 | NP | NP | |
| Paracoccidioides lutzii 8334 | > 500 | > 500 | 1 | 1 | NP | NP | |
| Paracoccidioides restrepiensis 234 | > 500 | > 500 | 1 | 1 | NP | NP | |
| Paracoccidioides brasiliensis 531 | 250 | 500 | 0.5 | 1 | NP | NP | |
| Paracoccidioides brasiliensis 326 | > 500 | > 500 | 0.5 | 2 | NP | NP | |
| Histoplasma capsulatum (ATCC 26029) | 1.95 | 3.90 | 1 | 1 | NP | NP | |
| Aspergillus fumigatus (ATCC 7100) | > 500 | > 500 | 1 | 1 | NP | NP | |
| Candida albicans (ATCC 90028) | 125 | 250 | 1 | 1 | 0.25 | CC | |
| Candida glabrata (ATCC 90030) | 125 | 500 | 1 | 1 | 16 | CC | |
| Candida parapsilosis (ATCC 22019) | 250 | 500 | 0.125 | 0.125 | 1.0 | CC | |
| Candida krusei (ATCC 6258) | 250 | 500 | 1 | 1 | 64.0 | CC | |
| Candida tropicalis (ATCC 750) | > 500 | > 500 | 0.5 | 0.5 | 1.0 | CC | |
| Cryptococcus neoformans (ATCC 28957) | 62.5 | 125 | 0.25 | 0.25 | 8 | CC | |
| Cryptococcus gattii (ATCC AFLP4) | 62.5 | 125 | 1 | 1 | 4 | CC | |
NP: not performed because it is not the reference antifungal agent; CC: countless colonies.