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. 2020 Oct 14;46(6):2216–2224. doi: 10.3892/ijmm.2020.4758

Figure 4.

Figure 4

EGCG repressed CSC-like properties of lung cancer cells via inhibiting CLOCK. CLOCK (A) protein and (B) mRNA expression level in A549 sphere cells. Cells were treated with 0, 10, 20 or 40 µM of EGCG for 48 h. CLOCK (C) protein and (D) mRNA expression level in H1299 sphere cells. Cells were treated with 0, 10, 20 or 40 µM of EGCG for 48 h. Flow cytometry analyses of CD133+ cell ratios in (E) A549 and (F) H1299 sphere cells treated with or without 40 µM EGCG. Data are presented as the mean ± SD from at least triplicate experiments. *P<0.05, ***P<0.001. CSC, cancer stem cell; EGCG, epigallocatechin-3-gallate.