Table I.
Effects of OA on potential lipid biomarkers associated with hypertension in liver.
| Number | tR, min | VIP value | Formula | Metabolite | Adduct ion | m/z | Fold change
|
Pathway | |
|---|---|---|---|---|---|---|---|---|---|
| SH/NCa | OA/SHa | ||||||||
| 1 | 10.34 | 1.24 | C34H67NO3 | GluCer (d18:1/25:0) | [M-H]− | 825.70577 | 2.11 | 0.23 | Sphingolipid metabolism |
| 2 | 10.49 | 1.38 | C39H68O5 | DG (36:4) | [M+H]+ | 616.50624 | 2.34 | 0.42 | Glycerolipid metabolism |
| 3 | 10.47 | 1.24 | C50H95NO13 | LacCer (d18:1/20:0) | [M+H]+ | 917.68544 | 0.36 | 1.96 | Sphingolipid metabolism |
| 4 | 11.93 | 1.78 | C55H105NO13 | LacCer (d18:1/25:0) | [M+H]+ | 987.75350 | 0.29 | 2.28 | Sphingolipid metabolism |
| 5 | 9.21 | 1.51 | C26H52NO7P | LysoPC (18:1) | [M-H]− | 521.34950 | 4.34 | 0.60 | Glycerophospholipid metabolism |
| 6 | 11.63 | 1.10 | C43H85O8P | PA (40:0) | [M-H]− | 759.5954 | 2.51 | 0.43 | Glycerophospholipid metabolism |
| 7 | 10.14 | 1.52 | C40H76NO8P | PC (32:2) | [M-H]− | 729.53166 | 2.19 | 0.32 | Glycerophospholipid metabolism |
| 8 | 10.49 | 1.32 | C42H80NO8P | PC (34:2) | [M-H]− | 757.56290 | 2.54 | 0.32 | Glycerophospholipid metabolism |
| 9 | 9.52 | 1.61 | C42H76NO8P | PC (34:4) | [M-H]− | 753.53070 | 2.05 | 0.43 | Glycerophospholipid metabolism |
| 10 | 10.22 | 1.37 | C37H74NO8P | PE (32:0) | [M-H]− | 691.51380 | 0.15 | 2.78 | Glycerophospholipid metabolism |
| 11 | 13.73 | 1.01 | C45H93N2O6P | SM (d18:0/22:0) | [M-H]− | 788.67284 | 0.30 | 1.42 | Sphingolipid metabolism |
| 12 | 16.40 | 1.52 | C59H92O6 | TG (56:11) | [M+H]+ | 896.68605 | 2.10 | 0.40 | Glycerolipid metabolism |
| 13 | 15.83 | 1.60 | C61H92O6 | TG (58:13) | [M+H] + | 920.68623 | 2.94 | 0.33 | Glycerolipid metabolism |
| 14 | 11.16 | 1.31 | C60H111NO18 | TriCer (d18:1/24:1) | [M-H]− | 1133.7749 | 0.12 | 8.01 | Sphingolipid metabolism |
a
P<0.01. NC, negative control; SH, spontaneously hypertensive; OA, oleanolic acid; tR, retention time; VIP, variable importance in projection; LacCer, lactosylceramide; TriCer, trihexosylceramide; GluCer, glucosylceramide; SM, sphingomyelin; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PA, phosphatidic acid; lysoPC, lysophosphatidylcholine; DG, diglyceride; TG, triglyceride.