Skip to main content
. 2020 Oct 9;46(6):2007–2018. doi: 10.3892/ijmm.2020.4750

Figure 1.

Figure 1

The downregulation of long intergenic non-coding RNA (LINC)01232 suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in esophageal squamous cell carcinoma (ESCC). (A) GEPIA was used to analyze LINC01232 expression in ESCC tissues (n=182) and normal tissues (n=286). (B) LINC01232 expression in 55 pairs of ESCC tissues and matched normal tissues was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). (C) LINC01232 expression was detected in 3 ESCC cell lines (Eca109, TE-1 and KYSE150) and a normal human esophageal epithelial cell line (HET-1A) by RT-qPCR. (D and E) The association of LINC01232 expression with overall survival and disease-free survival in patients with ESCC were analyzed using GEPIA. (F) The silencing efficiency of si-LINC01232 against LINC01232 expression in Eca109 and KYSE150 cells was analyzed by RT-qPCR. (G and H) CCK-8 assay and flow cytometry were performed to measure the proliferation and apoptosis of Eca109 and KYSE150 cells subjected to LINC01232 depletion. (I and J) The migratory and invasive capabilities of Eca109 and KYSE150 cells following si-LINC01232 or si-ctrl transfection were evaluated using migration and invasion assays, respectively. *P<0.05 and **P<0.01 vs. normal tissues or si-ctrl.