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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Allergy Clin Immunol. 2019 Nov;144(5):1150–1153. doi: 10.1016/j.jaci.2019.09.014

Figure 2. Schematic representation of the information provided by single-cell analysis.

Figure 2.

Top panel shows the distribution of four immune cell subsets in a healthy individual. The bottom panel illustrates the possibilities that can happen in diseased states: either the relative proportion of one cell subset is increased without changes in their molecular program (quantitative change) and/or cells in one subset change their molecular program (qualitative change); such differences can be captured by single-cell analyses.