Table 3.
Ventilatory and hemodynamic variables during transient elevations of the positive end-expiratory pressure to three levels
| Variables | Baseline PEEP 5cmH2O |
PEEP1 Level 10cmH2O |
PEEP2 level 15cmH2O |
PEEP3 level 20cmH2O |
|---|---|---|---|---|
| Ventilatory | ||||
| Peak pressure in cmH2O | 22 (19 - 24) | 27 (24 - 28)* | 34 (29 - 36)* | 40 (37 - 45)* |
| Plateau pressure in cmH2O | 15 (13 - 18) | 20 (18 - 22)* | 26 (24 - 28)* | 33 (31 - 37)* |
| Hemodynamic | ||||
| HR (bpm) | 98 (81 - 110) | 99 (81 - 109) | 99 (83 - 110) | 100 (83 - 110) |
| CVP (mmHg) | 7.5 (5 - 11.5) | 10 (6 - 12) | 10.5 (8 - 13.5) | 12.5 (8 - 14) |
| SBP (mmHg) | 115 (123 - 127) | 113 (94 - 122) | 101 (88 - 115) | 93 (77 - 109) |
| MAP (mmHg) | 77 (69 - 84) | 77 (69 - 82) | 73 (66 - 80)† | 69 (58 - 75)† |
| PPV (%) | 13 (6 - 16) | 14 (11 - 17) | 16 (11 - 24)† | 19 (12 - 26)* |
| SBP < 90mmHg | 0 | 2 (8.3%) | 7 (29.2)† | 10 (41.6)* |
| MAP < 60mmHg | 0 | 1 (4.1%) | 5 (20.8)† | 7 (29.2)* |
PEEP - positive end-expiratory pressure; PEEP1 - increase in positive end-expiratory pressure from 5 to 10cmH2O; PEEP2 - increase in positive end-expiratory pressure from 5 to 15cmH2O; PEEP3 - increase in positive end-expiratory pressure from 5 to 20cmH2O; HR - heart rate; CVP - central venous pressure; SBP - systolic blood pressure; MAP - mean arterial pressure; PPV - pulse pressure variation.
*
p < 0.001;
†
p < 0.01. Results expressed as mean ± standard deviation or n (%).