Table 2.
Analysis of factors influencing Ln-RHI
| Categorical variables (t-test for means) | ||||
|---|---|---|---|---|
| Univariate analysis | Multivariable analysis | |||
| Yes | No | p value | p value; B (95%CI for OR) | |
| Sex - male | 0.59 ± 0.51 | 0.54 ± 0.33 | 0.617 | NS |
| Age ≥ 60 y.o. | 0.44 ± 0.47 | 0.67 ± 0.43 | 0.023 | NS |
| DM2 | 0.49 ± 0.42 | 0.61 ± 0.48 | 0.347 | NS |
| Arterial hypertension | 0.50 ± 0.46 | 0.65 ± 0.45 | 0.127 | NS |
| Dyslipidemia | 0.44 ± 0.47 | 0.68 ± 0.43 | 0.015 | 0.03; -0.908 (-1.463; -0.320) |
| Statins use | 0.43 ± 0.47 | 0.65 ± 0.43 | 0.031 | 0.029; 0.547 (0.058; 1.035) |
| Peripheral arterial disease | 0.58 ± 0.47 | 0.57 ± 0.44 | 0.939 | < 0.01; 0.490 (0.220; 0.880) |
| COPD | 0.47 ± 0.52 | 0.60 ± 0.45 | 0.351 | NS |
| Autoimmune disease | 0.60 ± 0.68 | 0.57 ± 0.45 | 0.911 | NS |
| Smoking habits | 0.55 ± 0.56 | 0.59 ± 0.41 | 0.709 | NS |
| Coronary disease | 0.42 ± 0.46 | 0.64 ± 0.45 | 0.047 | 0.02; -0.304 (-0.590; -0.040) |
| Hematological cancer | 1.06 ± 0.39 | 0.56 ± 0.45 | 0.135 | NS |
| HIV | 0.61 ± 0.43 | 0.57 ± 0.46 | 0.775 | NS |
| Metastatic solid neoplasia | 0.07 ± 0.51 | 0.63 ± 0.42 | < 0.01 | < 0.01; -0.275 (-0.72; -0.11) |
| Shock | 0.31 ± 0.41 | 0.79 ± 0.39 | < 0.01 | < 0.01; -0.261 (-0.53; -0.07) |
| Continuous variables (Pearson’s correlation) | ||||
| Univariate analysis | Multivariable analysis | |||
| Pearson’s r | p value | p value; B (95%CI for the OR) | ||
| APACHE II score | -0.406 | < 0.01 | < 0.01; -0.362 (-0.039 to -0.010) | |
| SAPS 2 score | -0.359 | < 0.01 | < 0.01; -0.320 (-0.013 to -0.003) | |
| SOFA score | -0.314 | < 0.01 | < 0.01; -0.414 (-0.067 to -0.022) | |
| MAP (mmHg) | 0.341 | 0.001 | NS | |
| Ionized calcium (mmol/L) | 0.201 | 0.540 | NS | |
| pH | 0.206 | 0.067 | NS | |
| pCO2 (mm Hg) | -0.140 | 0.895 | NS | |
| Potassium (mEq/L) | -0.224 | 0.023 | NS | |
| Temperature (Celsius) | 0.071 | 0.546 | NS | |
| Respiratory rate (beats/minute) | -0.102 | 0.556 | NS | |
| CRP (mg/L) | -0.135 | 0.445 | NS | |
| Lactate (mmol/L) | -0.499 | < 0.01 | 0.01; 0.410 (-0.117 to 0.936) | |
| Noradrenaline (mcg/kg/minute) | -0.348 | < 0.01 | NS | |
| Ln_endocan (pg/mL) | -0.137 | 0.265 | NS | |
| Ln_syndecan-1 (pg/mL) | -0.346 | < 0.01 | 0.010; -0.276 (-0.483 to -0.069) | |
| Ln_E-selectin (pg/mL) | -0.005 | 0.965 | 0.024; -0.245 (-0.273 to -0.02) | |
| Endothelin-1 (pg/mL) | 0.027 | 0.832 | NS | |
APACHE II - Acute Physiology and Chronic Health Evaluation II; B - coefficient; BMI - body mass index; COPD - chronic obstructive pulmonary disease; CRP - C-reactive protein; DM2 - Diabetes Mellitus II; Ln - natural logarithm; PAT - peripheral arterial tonometry; OR - odds ratio; RHI - reactive hyperemia index; SAPS II - Simplified Acute Physiology Score II; SOFA - Sequential Organ Failure Assessment.