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. 2020 Aug 20;11(4):573–580. doi: 10.1055/s-0040-1714314

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Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. https://creativecommons.org/licenses/by-nc-nd/4.0/.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 3 — Association of severity of ALS (minimum, mild, and moderate–severe) based on ALS FRS-R score with ( A ) optineurin (OPTN), ( B ) MCP-1 (monocyte chemoattractant protein-1) ( C ) VEGF (vascular endothelial growth factor), ( D ) angiogenin (ANG), ( E ) TDP-43 (TAR DNA binding protein) and ( F ) VEGFR2 (VEGF receptor 2) in ALS patients. Data are represented as mean with standard error as error bar. Significance was calculated by Kruskal–Wallis test and considered at p ≤ 0.05. ALS, amyotrophic lateral sclerosis; FRS, functional ration scale; NS, nonsignificant.