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. 2020 Oct 16;14:575626. doi: 10.3389/fncel.2020.575626

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Copyright © 2020 Ge and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PICs on neuronal excitability. (A) Example of riluzole (2 μM, black trace) reduced the firing frequency of 5-HT neuron compared to that of pre-riluzole (gray trace) and depolarized the Vth in control group. (B) Example of riluzole (2 μM, black trace) reduced the firing frequency of 5-HT neuron compared to that of pre-riluzole (gray trace) and depolarized the Vth in the exercise group. (C) Exercise training significantly depolarized the Vth (left panel, unpaired Student’s t-test, p = 0.044). After administration of riluzole, there was no significant difference in Vth between the control and exercise groups (right panel, unpaired Student’s t-test, p = 0.248). (D) Compared with the control group, exercise training increased the number of APs (left panel, unpaired Student’s t-test, p = 0.029). Even reduced by riluzole, the number of AP measured from the exercise group were still bigger than those from the control group (right panel, unpaired Student’s t-test, p = 0.034). (E) Example of nimodipine (25 μM) reduced the firing frequency of 5-HT neuron compared to that of pre-nimodipine (gray trace). (F) Example of nimodipine (25 μM) reduced the firing frequency of 5-HT neuron compared to that of pre-nimodipine (gray trace) in the exercise group. (G) Exercise training significantly hyperpolarized the Vth (left panel, unpaired Student’s t-test, p = 0.026). Significant difference was also observed in Vth between control and exercise groups with nimodipine (right panel, unpaired Student’s t-test, p = 0.013). (H) Compared with the control group, exercise training increased the number of APs (left panel, unpaired Student’s t-test, p = 0.025). After administration of nimodipine, there was no significant difference in the number of APs between control and exercise groups (right panel, unpaired Student’s t-test, p = 0.352). *p < 0.05.