Calciphylaxis is a progressive disease with high mortality.

Treatment of pain must be multimodal and should target the underlying disease etiology, as pain is often associated with the primary disease burden. Any attempt at analgesia and symptomatic management should be coupled with proper wound care and modification of underlying risk factors.

Various available therapeutic options include parathyroidectomy, sodium thiosulfate, optimization of renal impairment, cessation of offending drugs, and multimodal analgesic regimens.

Currently, there are multiple clinical trials in progress in order to provide relief to patients with this debilitating disease.