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. 2020 Oct 29;10:18587. doi: 10.1038/s41598-020-75783-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Associations between nuclear and cytoplasmic HMGB1 expression with survival of patients with colorectal cancer. (A,B). Associations of nuclear HMGB1 expression with overall survival (OS) (A) and relapse-free survival (RFS) (B) were analyzed in the colorectal cancer cohort. (C,D). Associations of cytoplasmic HMGB1 expression with OS (C) and RFS (D) were analyzed in the colorectal cancer cohort. P-values were calculated using the Mantel-Cox log-rank test.