Table 4.
Association of nuclear and cytoplasmic HMGB1 expression with clinical pathologic parameters in patients with colorectal cancer.
| Variables | No | Strongly positive nuclear HMGB1 expression, n (%) | P-value | Positive cytoplasmic HMGB1 expression, n (%) | P-value |
|---|---|---|---|---|---|
| Gender | |||||
| Male | 217 | 181 (83.4%) | 0.707 | 49 (22.6%) | 0.166 |
| Female | 152 | 129 (84.9%) | 44 (28.9%) | ||
| Age (years) | |||||
| < 60 | 105 | 93 (88.6%) | 0.132 | 20 (19.0%) | 0.086 |
| ≥ 60 | 264 | 217 (82.2%) | 73 (27.7%) | ||
| Tumor site | |||||
| Right colon | 92 | 82 (89.1%) | 0.289 | 25 (27.2%) | 0.682 |
| Left colon | 84 | 70 (83.3%) | 23 (27.4%) | ||
| Rectum | 193 | 158 (81.9%) | 45 (23.3%) | ||
| Tumor grade | |||||
| Low | 35 | 29 (82.9%) | 0.845 | 3 (8.6%) | 0.017 |
| High | 334 | 281 (84.1%) | 90 (26.9%) | ||
| Depth of invasion | |||||
| Tis + T1 | 11 | 9 (81.8%) | 0.748 | 2 (18.2%) | 0.833 |
| T2 | 55 | 45 (81.8%) | 15 (27.3%) | ||
| T3 | 89 | 78 (87.6%) | 20 (22.5%) | ||
| T4 | 214 | 178 (83.2%) | 56 (26.2%) | ||
| Lymph node metastases | |||||
| − | 203 | 173 (85.2%) | 0.483 | 47 (23.2%) | 0.316 |
| + | 166 | 137 (82.5%) | 46 (27.7%) | ||
| Tumor stage | |||||
| I | 47 | 40 (85.1%) | 0.634 | 12 (25.5%) | 0.847 |
| II | 149 | 127 (85.2%) | 34 (22.8%) | ||
| III | 144 | 117 (81.3%) | 39 (27.1%) | ||
| IV | 29 | 26 (89.7%) | 8 (27.6%) | ||