Figure 1.

Thermosensory neurons regulate cold tolerance and temperature acclimatisation in C. elegans. (a) Cultivation conditions for the temperature acclimatisation assay. 15 °C-cultivated N2 wild-type animals can survive at 2 °C. 25 °C-cultivated N2 wild-type animals failed to survive at 2 °C. When 15 °C-cultivated wild-type animals were transferred and conditioned at 25 °C for 3 or 5 h, they exhibited decreased survival at 2 °C. (b) Cold tolerance and temperature acclimatisation are regulated by a subset of sensory neurons. ADL sensory neurons can detect temperature, and TRPV channels in ADL are involved in temperature acclimatisation.