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. 2020 Oct 29;10:18677. doi: 10.1038/s41598-020-75807-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The rate of change of MT2A-expression vs. Apoptosis rate (A) and vs. viability-rate (B). Three phenotypes could be observed. MSTO-211H cells showed increased gene expression of MT2A and decreased apoptosis rates after cisplatin treatment. NCI-H2452 cells showed neither response to cisplatin treatment nor changes in apoptosis rates. NCI-H2052 cells showed the highest apoptosis rates, while MT2A expression was not changed after cisplatin treatment.