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. 2020 Jul 31;13(5):405–418. doi: 10.1007/s12195-020-00641-0

Table 2.

Bio-layer-interferometry measurements of soluble Fc-fused aflibercept variant protein interactions with immobilized VEGF-A.

Construct KD (pM) Kon (× 105 Ms−1) Koff (× 10−4 s−1)
Aflibercept 330 ± 3.9 7.1 ± 0.049 2.4 ± 0.023
C5 270 ± 28 6.6 ± 0.032 1.8 ± 0.016
D4 250 ± 34 5.7 ± 0.028 1.4 ± 0.018
F3 260 ± 28 6.4 ± 0.030 1.7 ± 0.016