Table 2.

Kidney function markers (serum BUN and urine creatinine) levels in healthy C57BL/6 after 24 and 48 h post-administration of KNP/MN, NP/MN, and PBS.

Sample	Blood urea nitrogen (mg/dL)	Creatinine (mg/dL)
KNP/MN patch, 24 h	46.7 ± 12.4	7.1 ± 2.1
KNP/MN patch, 48 h	38.3 ± 8.6	9.0 ± 1.5
Control NP/MN patch, 24 h	32.5± 14.1	8.3 ± 1.1
Control NP/MN patch, 48 h	26.4 ± 7.1	6.0 ± 2.7
PBS (IP), 48 h	21.9 ± 10.1	4.1 ± 3.8

^aHealthy mice serum BUN reported as ~ 25.0 to 75.0 mg/dL19

^bHealthy mice urine creatinine reported as ~ 4.7 ± 3.1 mg/dL46