FIGURE 1.

Tau degradation in healthy neurons. (A) Unmodified wildtype tau or mutant tau is degraded by e-MI; (B) Unmodified wildtype tau is degraded by CMA; (C) Phosphorylated tau and tau aggregates are degraded by macroautophagy; (D) Tau phosphorylated at specific sites is degraded by autophagy-independent endolysosomal pathway.