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. 2020 Oct 16;11:593289. doi: 10.3389/fimmu.2020.593289

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Copyright © 2020 Shamriz, Tal, Talmon and Nahum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Underlying mechanisms of immune responses against Candida spp. (A) Candida spp. recognition and initial immune response involve key molecules of the innate system. (B) Adaptive response against Candida spp. includes activation and differentiation of naïve CD4⁺ T cells into effector T helper 17 (Th17) cells. TLR, toll-like receptor; PKC-δ, Protein kinase C-δ; MYD-88, Myeloid differentiation primary response 88; NFκB, Nuclear factor kappa-light-chain-enhancer of activated B cells; IL-Interleukin; APC, Antigen presenting cell; TGF-β, Transforming growth factor beta (TGF-β); JAK-Janus Kinase; STAT, Signal transducer and activator of transcription; RORγT, RAR-related orphan receptor gamma.