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. 2020 Oct 29;10:18561. doi: 10.1038/s41598-020-75517-4

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental periodontitis and periodontal changes in a murine model of Alzheimer’s disease. (A) 5xFAD mice at baseline (not exposed to ligatures; Non-Lig) had higher level of bone loss than WT littermates. After induction of experimental periodontitis by the placement of ligatures (Lig), 5xFAD and WT mice both showed significant bone loss while no significant differences were detected between the level of bone loss in ligature-treated 5xFAD mice and ligature-treated WT mice. (B) Macroscopic findings were confirmed with histological measurement of alveolar bone levels in furcation region of the maxillary molar. (C) TRAP stained osteoclastic cells were significantly increased in 5xFAD mice compared to the WT mice at baseline. (*p < 0.05).