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. 2020 Oct 29;10:18561. doi: 10.1038/s41598-020-75517-4

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Amyloid beta (Aβ) accumulation and topographical distribution in the cortex, hippocampal formation, and dentate gyrus. (A) Soluble and insoluble forms of Aβ in brain extracts from 5xFAD mice with (Lig) or without (Non-Lig) experimental PD. *p < 0.05 compared to non-PD animals. (B) Photomicrographs of Aβ42-immunostained sections containing cortical layers 4–5 (CTX), the hippocampus (HPC), and the dentate gyrus (DG) subregion of the hippocampus, were taken with a 4 × objective from Non-Lig and Lig 5xFAD mouse brain sections. A constant threshold was applied to each image. Analysis of all thresholded Aβ42 particles was performed to obtain the percent area of Aβ42 staining.