Table 16.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Children and Adolescents (Age 0-19 Years), Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, Hispanic Ethnicityc, and Race, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2013-2017
| Histology | All Hispanic | White Hispanic | Black Hispanic | All Non-Hispanic | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 year total | Annual average | Rate | 95% CI | 5 year total | Annual average | Rate | 95% CI | 5 year total | Annual average | Rate | 95% CI | 5 year total | Annual average | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 2,977 | 595 | 2.96 | 2.85-3.07 | 2,704 | 541 | 3.04 | 2.93-3.16 | 82 | 16 | 1.34 | 1.06-1.66 | 12,805 | 2,561 | 4.17 | 4.09-4.24 |
| Pilocytic Astrocytoma | 651 | 130 | 0.64 | 0.60-0.70 | 591 | 118 | 0.66 | 0.61-0.72 | -- | -- | -- | -- | 3,084 | 617 | 1.01 | 0.97-1.04 |
| Diffuse Astrocytoma | 147 | 29 | 0.15 | 0.12-0.17 | 134 | 27 | 0.15 | 0.13-0.18 | -- | -- | -- | -- | 807 | 161 | 0.26 | 0.24-0.28 |
| Anaplastic Astrocytoma | 85 | 17 | 0.09 | 0.07-0.11 | 76 | 15 | 0.09 | 0.07-0.11 | -- | -- | -- | -- | 309 | 62 | 0.10 | 0.09-0.11 |
| Unique Astrocytoma Variants | 108 | 22 | 0.11 | 0.09-0.13 | 97 | 19 | 0.11 | 0.09-0.13 | -- | -- | -- | -- | 382 | 76 | 0.12 | 0.11-0.14 |
| Malignant | 48 | 10 | 0.05 | 0.04-0.07 | 45 | 9 | 0.05 | 0.04-0.07 | -- | -- | -- | -- | 189 | 38 | 0.06 | 0.05-0.07 |
| Non-Malignant | 60 | 12 | 0.06 | 0.05-0.08 | 52 | 10 | 0.06 | 0.04-0.08 | -- | -- | -- | -- | 193 | 39 | 0.06 | 0.05-0.07 |
| Glioblastoma | 152 | 30 | 0.15 | 0.13-0.18 | 143 | 29 | 0.16 | 0.14-0.19 | -- | -- | -- | -- | 565 | 113 | 0.18 | 0.17-0.20 |
| Oligodendroglioma | 21 | 4 | 0.02 | 0.01-0.03 | 20 | 4 | 0.02 | 0.01-0.04 | -- | -- | -- | -- | 154 | 31 | 0.05 | 0.04-0.06 |
| Anaplastic Oligodendroglioma | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 20 | 4 | 0.01 | 0.00-0.01 |
| Oligoastrocytic Tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 54 | 11 | 0.02 | 0.01-0.02 |
| Ependymal Tumors | 255 | 51 | 0.25 | 0.22-0.29 | 236 | 47 | 0.27 | 0.23-0.30 | -- | -- | -- | -- | 936 | 187 | 0.30 | 0.29-0.32 |
| Malignant | 220 | 44 | 0.22 | 0.19-0.25 | 205 | 41 | 0.23 | 0.20-0.26 | -- | -- | -- | -- | 777 | 155 | 0.25 | 0.24-0.27 |
| Non-Malignant | 35 | 7 | 0.04 | 0.03-0.05 | 31 | 6 | 0.04 | 0.02-0.05 | -- | -- | -- | -- | 159 | 32 | 0.05 | 0.04-0.06 |
| Glioma Malignant, NOS | 515 | 103 | 0.51 | 0.47-0.56 | 456 | 91 | 0.51 | 0.47-0.56 | 21 | 4 | 0.33 | 0.20-0.51 | 2,470 | 494 | 0.81 | 0.78-0.84 |
| Choroid Plexus Tumors | 101 | 20 | 0.10 | 0.08-0.12 | 93 | 19 | 0.10 | 0.08-0.13 | -- | -- | -- | -- | 307 | 61 | 0.10 | 0.09-0.11 |
| Malignant | 23 | 5 | 0.02 | 0.01-0.03 | 21 | 4 | 0.02 | 0.01-0.04 | -- | -- | -- | -- | 81 | 16 | 0.03 | 0.02-0.03 |
| Non-Malignant | 78 | 16 | 0.08 | 0.06-0.10 | 72 | 14 | 0.08 | 0.06-0.10 | -- | -- | -- | -- | 226 | 45 | 0.07 | 0.06-0.08 |
| Other Neuroepithelial Tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 23 | 5 | 0.01 | 0.00-0.01 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal Glial Tumors | 327 | 65 | 0.33 | 0.30-0.37 | 294 | 59 | 0.34 | 0.30-0.38 | -- | -- | -- | -- | 1,596 | 319 | 0.51 | 0.49-0.54 |
| Malignant | 24 | 5 | 0.02 | 0.02-0.04 | 22 | 4 | 0.03 | 0.02-0.04 | -- | -- | -- | -- | 87 | 17 | 0.03 | 0.02-0.03 |
| Non-Malignant | 303 | 61 | 0.31 | 0.27-0.34 | 272 | 54 | 0.31 | 0.28-0.35 | -- | -- | -- | -- | 1,509 | 302 | 0.49 | 0.46-0.51 |
| Tumors of the Pineal Region | 44 | 9 | 0.04 | 0.03-0.06 | 38 | 8 | 0.04 | 0.03-0.06 | -- | -- | -- | -- | 167 | 33 | 0.05 | 0.05-0.06 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 139 | 28 | 0.05 | 0.04-0.05 |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 28 | 6 | 0.01 | 0.01-0.01 |
| Embryonal Tumors | 545 | 109 | 0.53 | 0.49-0.58 | 503 | 101 | 0.56 | 0.51-0.61 | -- | -- | -- | -- | 1,931 | 386 | 0.63 | 0.61-0.66 |
| Medulloblastoma | 350 | 70 | 0.35 | 0.31-0.38 | 326 | 65 | 0.36 | 0.33-0.41 | -- | -- | -- | -- | 1,286 | 257 | 0.42 | 0.40-0.45 |
| Primitive neuroectodermal tumors | 58 | 12 | 0.06 | 0.04-0.07 | 53 | 11 | 0.06 | 0.04-0.08 | -- | -- | -- | -- | 183 | 37 | 0.06 | 0.05-0.07 |
| Atypical teratoid rhabdoid tumor | 85 | 17 | 0.08 | 0.06-0.10 | 78 | 16 | 0.08 | 0.07-0.11 | -- | -- | -- | -- | 295 | 59 | 0.10 | 0.09-0.11 |
| Other embryonal histologies | 52 | 10 | 0.05 | 0.04-0.07 | 46 | 9 | 0.05 | 0.04-0.07 | -- | -- | -- | -- | 167 | 33 | 0.05 | 0.05-0.06 |
| Tumors of Cranial and Spinal Nerves | 243 | 49 | 0.25 | 0.22-0.28 | 213 | 43 | 0.24 | 0.21-0.28 | -- | -- | -- | -- | 1,046 | 209 | 0.34 | 0.32-0.36 |
| Nerve Sheath Tumors | 242 | 48 | 0.24 | 0.21-0.28 | 212 | 42 | 0.24 | 0.21-0.28 | -- | -- | -- | -- | 1,044 | 209 | 0.34 | 0.32-0.36 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | - |
| Other Tumors of Cranial and Spinal Nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 244 | 49 | 0.25 | 0.22-0.28 | 221 | 44 | 0.26 | 0.22-0.29 | -- | -- | -- | -- | 887 | 177 | 0.28 | 0.26-0.30 |
| Meningioma | 125 | 25 | 0.13 | 0.11-0.15 | 112 | 22 | 0.13 | 0.11-0.16 | -- | -- | -- | -- | 523 | 105 | 0.17 | 0.15-0.18 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 26 | 5 | 0.01 | 0.01-0.01 |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 497 | 99 | 0.16 | 0.14-0.17 |
| Mesenchymal Tumors | 66 | 13 | 0.07 | 0.05-0.08 | 60 | 12 | 0.07 | 0.05-0.09 | -- | -- | -- | -- | 200 | 40 | 0.07 | 0.06-0.07 |
| Primary Melanocytic Lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Neoplasms Related to the Meninges | 50 | 10 | 0.05 | 0.04-0.07 | 47 | 9 | 0.06 | 0.04-0.07 | -- | -- | -- | -- | 155 | 31 | 0.05 | 0.04-0.06 |
| Lymphoma and Hematopoietic Neoplasms | 22 | 4 | 0.02 | 0.01-0.03 | 19 | 4 | 0.02 | 0.01-0.03 | -- | -- | -- | -- | 100 | 20 | 0.03 | 0.03-0.04 |
| Lymphoma | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 46 | 9 | 0.01 | 0.01-0.02 |
| Other Hematopoietic Neoplasms | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 54 | 11 | 0.02 | 0.01-0.02 |
| Germ Cell Tumors and Cysts | 246 | 49 | 0.25 | 0.22-0.28 | 224 | 45 | 0.26 | 0.22-0.29 | -- | -- | -- | -- | 746 | 149 | 0.24 | 0.22-0.26 |
| Germ Cell Tumors, Cysts and Heterotopias | 246 | 49 | 0.25 | 0.22-0.28 | 224 | 45 | 0.26 | 0.22-0.29 | -- | -- | -- | -- | 746 | 149 | 0.24 | 0.22-0.26 |
| Malignant | 195 | 39 | 0.20 | 0.17-0.23 | 177 | 35 | 0.21 | 0.18-0.24 | -- | -- | -- | -- | 579 | 116 | 0.19 | 0.17-0.20 |
| Non-Malignant | 51 | 10 | 0.05 | 0.04-0.07 | 47 | 9 | 0.05 | 0.04-0.07 | -- | -- | -- | -- | 167 | 33 | 0.05 | 0.05-0.06 |
| Tumors of Sellar Region | 1,139 | 228 | 1.19 | 1.12-1.26 | 1,024 | 205 | 1.20 | 1.13-1.28 | 34 | 7 | 0.60 | 0.42-0.84 | 3,108 | 622 | 0.99 | 0.95-1.02 |
| Tumors of the Pituitary | 951 | 190 | 1.00 | 0.94-1.07 | 847 | 169 | 1.00 | 0.94-1.07 | -- | -- | -- | -- | 2,435 | 487 | 0.77 | 0.74-0.80 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | - | -- | -- | -- | -- |
| Craniopharyngioma | 188 | 38 | 0.19 | 0.16-0.22 | 177 | 35 | 0.20 | 0.17-0.23 | -- | -- | -- | -- | 673 | 135 | 0.22 | 0.20-0.24 |
| Unclassified Tumors | 335 | 67 | 0.34 | 0.30-0.38 | 291 | 58 | 0.33 | 0.30-0.37 | -- | -- | -- | -- | 1,174 | 235 | 0.38 | 0.36-0.40 |
| Hemangioma | 135 | 27 | 0.14 | 0.11-0.16 | 124 | 25 | 0.14 | 0.12-0.17 | -- | -- | -- | -- | 463 | 93 | 0.15 | 0.14-0.16 |
| Neoplasm Unspecified | 194 | 39 | 0.20 | 0.17-0.23 | 161 | 32 | 0.18 | 0.16-0.22 | -- | -- | -- | -- | 677 | 135 | 0.22 | 0.20-0.24 |
| Malignant | 50 | 10 | 0.05 | 0.04-0.07 | 42 | 8 | 0.05 | 0.03-0.06 | -- | -- | -- | -- | 168 | 34 | 0.05 | 0.05-0.06 |
| Non-Malignant | 144 | 29 | 0.15 | 0.12-0.17 | 119 | 24 | 0.14 | 0.11-0.16 | -- | -- | -- | -- | 509 | 102 | 0.16 | 0.15-0.18 |
| All Other | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 34 | 7 | 0.01 | 0.01-0.02 |
| TOTAL d | 5,206 | 1,041 | 5.26 | 5.11-5.40 | 4,696 | 939 | 5.36 | 5.21-5.52 | 148 | 30 | 2.47 | 2.09-2.90 | 19,866 | 3,973 | 6.42 | 6.33-6.51 |
| Malignant | 2,797 | 559 | 2.78 | 2.68-2.88 | 2,544 | 509 | 2.86 | 2.75-2.98 | 76 | 15 | 1.23 | 0.97-1.54 | 11,650 | 2,330 | 3.79 | 3.72-3.86 |
| Non-Malignant | 2,409 | 482 | 2.48 | 2.38-2.58 | 2,152 | 430 | 2.50 | 2.39-2.61 | 72 | 14 | 1.24 | 0.97-1.56 | 8,216 | 1,643 | 2.63 | 2.57-2.69 |
a. Annual average cases are calculated by dividing the five year total by five.
b. Rates are per 100,000 and are age-adjusted to the 2000 US standard population.
c. Hispanic ethnicity is not mutually exclusive of race; Classified using the North American Association of Central Cancer Registries Hispanic Identification Algorithm, version 2 (NHIA v2).
d. Refers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 20 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.